Wolves dropped to 4th in the Championship after they lost 2-0 to Sheffield United at Bramall Lane last night.
Conor Coady was dismissed after 15 minutes after a clear pull back on Leon Clarke who was about to race through to have a one-on-one.
Inevitably, that seriously swayed the game in the Blades favour.
Wolves sat back and deservedly went behind when Clarke tapped home from a terrific Enda Stevens cross.
Ruben Neves later missed a penalty before ex-Wolves man Clarke bagged his second.
After the game, Wanderers captain Danny Batth took to Twitter to praise his sides spirit in the second half and the support of the sell-out away crowd that made the trip up to Yorkshire.
Tough one to take after a solid start!
Its a long season and with the 2nd half spirit & that travelling support we will bounceback #wwfc
— Danny Batth 'Bart' (@Danny_Batth) September 27, 2017
Nuno Espirito Santo will be looking for his side to bounce back straight away on Saturday when they go to Burton Albion.
The Brewers will also be desperate to get back out there having lost emphatically at home to Aston Villa in the week.
With Coady missing, Santo is likely to turn to Kortney Hause to step into the three-man defence, and he will add balance by playing on the left-side of the trio.
It would be a first appearance for the England U-21 international who only returned to the squad this month after an injury.
Conor Coady will be wondering why he made the decision to foul Clarke, with so long left in the game even if the striker had scored.
He gave his side a mountain to climb and although they showed spirit in the second half as Danny Batth mentions, they never looked like getting a point once Neves missed the penalty.
After a strong start Wolves will now need to show they have the character to deal with a setback when they face Burton Albion away on Saturday.
What do you think Wolves fans? Can you take any positives from last night? Let us know in the comments below.