The Blades were beaten 1-0 by fellow promotion hopefuls Watford on Monday evening as Joao Pedro’s goal proved the difference between the two sides at Vicarage Road.
Millwall, meanwhile, sit top of the table after a confidence-boosting 2-0 victory over Stoke City at The Den last weekend.
Leeds United loanee Charlie Cresswell made the perfect start to his time with the Lions – with the centre-back scoring a brace and helping his side to keep a clean sheet.
It’s not all been plain sailing for Gary Rowett’s team, however, as they were knocked out of the EFL Cup in midweek by Cambridge United of League One.
They’ll hope to get back to winning ways on Saturday while the Blades would love to pick up their first three points of 2022/23 to kick off their promotion push.
However, on the Sky Sports website, Prutton has predicted that they will have to settle for a 2-2 draw.
He explained: “Sheffield United were never out of the game against Watford on Monday, but aside from a few fleeting moments, they never looked like scoring either.
“Young forwards Daniel Jebbison and Iliman Ndiaye put in impressive performances and I’m looking forward to seeing them develop this term.
“Millwall were one of only two teams to score more than one goal throughout the opening weekend and both came from centre-back Charlie Cresswell, who probably couldn’t believe his luck.
“Gary Rowett’s men are so good from set-pieces and will be keen to cause other teams problems with them over the next few months. This could be a very entertaining score draw.”
Quiz: Can you name which club Sheffield United signed these 25 English players from?
A draw does look a likely result at Bramall Lane but four goals would be a high-scoring affair between these two sides.
Both Millwall’s goals came from corners last weekend and though they promise to be a threat from set pieces again, they’re still developing as an attacking side following the departure of Jed Wallace and the arrival of some new faces.
The Blades, meanwhile, struggled for creativity against Watford and now come up against a team that have proven themselves very difficult to break down.
Rowett’s side are well organised and structured so United are going to have to work hard for their opportunities.
It would be no surprise to see a low scoring game at Bramall Lane.