Wigan Athletic are looking to finally get their season up and running against the side who were the first visitors to the DW Stadium in 2000.
That League Cup tie was the last time the sides met as Wigan went on a mission which resulted in them spending eight seasons in the Premier League, while Scunthorpe found themselves regularly swapping and changing divisions.
Those years in the top-flight seem like a distant memory for the Latics who, following two relegations in three seasons, are looking to return to the Championship at the first time of asking.
Their mission has not started as they would have wanted, though, as they opened with a 2-0 defeat at Coventry City, before playing out a goalless stalemate with Doncaster Rovers after going out of the Capital One Cup to Bury.
Scunthorpe got their first win on the board at the weekend, as they overcame Crewe Alexandra 2-0 at Glanford Park after suffering an opening-day defeat to League One new boys Burton Albion.
Their chances this evening have received a boost, too, with captain Stephen Dawson returning from injury after missing out against Crewe.