Given that the Whites’ goal difference is 27 superior to Bournemouth, it is almost guaranteed that a point will win the London club the Championship title.
Tomorrow also presents the Cottagers with the opportunity to surpass 100 league goals, which is a record that is yet to be hit in the Championship era.
There is lots still riding on Luton’s season with a couple of games left to play, with Nathan Jones’ side in fifth place.
The Hatters are in need of two more points to guarantee a spot in this season’s play-offs, whilst a point could prove to be enough.
Even if they are defeated at Craven Cottage, the Hatters will find themselves in the front seat going into the final game of the campaign at home to Reading.
Quiz: Which club did Fulham sign these 24 players from in the 1990s?
Latest team news
Antonee Robinson may require a minor knee operation so that he is able to ready himself for the World Cup and the start of Fulham’s Premier League campaign, with Joe Bryan likely to continue playing in his absence.
Terence Kongolo will also be sidelined as Fulham attempt to seal the Championship title at home to the Hatters.
It is also Fabio Carvalho’s last outing at Craven Cottage ahead of his move to Liverpool, with the academy graduate a likely starting XI candidate.
As for Luton, there remains to be a great deal of uncertainty as to who will be available.
In somewhat of an injury crisis, club photographer Gareth Owen’s latest set of shots has given any indication as to who might be back available.
Quiz: Which club did Luton Town sign these 24 players from in the 1990s?
The likes of Reece Burke, Jordan Clark and Fred Onyedinma were also pictured back on the training pitch.
Elijah Adebayo is likely to be a notable absentee after causing the Whites a lot of problems during the return fixture.
The Whites may have only picked up four points from their last five games, however, with a slightly longer break in-between games, they may be back to their best.
The Whites have proven devastating at times this season, whilst the Hatters have shown excellent levels of resilience, making it difficult to see how this one might pan out.
Fulham have proven to be a level above all during this campaign, and subsequently, a 3-1 victory seems a fair assessment.
How to watch?
Tonight’s fixture will be shown on Sky Sports main event, which means that there will be no live FFCtv or iFollow stream in countries where the EFL has an overseas broadcast deal
What time is kick-off?
Kick-off is at 17:15 BST.