Jody Morris has shared an emotional message ahead of his return to Chelsea as Derby County's assistant manager, saying it is the first time he has ever wanted the Blues to lose.
As well as Frank Lampard and Morris, Fikayo Tomori and Mason Mount will get the chance to play against their parent club on Wednesday night.
The former midfielder graduated through the youth system at Chelsea, making his debut for the club in the 1995/96 season.
He went on to make 159 appearances for the Blues before leaving for Leeds United in 2003.
Lampard will be hoping of causing another cup upset when he leads his side out at Stamford Bridge on Wednesday night.
The Rams knocked Manchester United out of the competition on penalties at Old Trafford in the last round after a 2-2 draw in 90 minutes.